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The relevance of the work is determined by the need to expand knowledge about the characteristics of the concentration and distribution of chemical elements in the organs and tissues of mammals, as indicators of the potential negative impact on the health of the population. The article discusses the influence of anthropogenic environmental impact on the formation of the elemental composition of a mammalian organism on the example of the domestic pig organs and tissues (Susscrofusdomesticus) sampled in the city of Ekibastuz, Pavlodar region of the Republic of Kazakhstan. The article studies the laws of concentration of chemical elements in the digestive system as a whole and its individual components. The accumulation of As, Br, in the oropharynx, Lu in the stomach, Rb, U in the small intestine, Sb in the large intestine, Au, Ag in the rectum is especially noted. It is proved that the digestive system of a domestic pig reacts to human impact, forming powerful biochemical barriers. The concentration of chemical elements varies depending on the part of the gastrointestinal tract, as the acid-base balance changes and depending on the physiological function of the organs studied. It has been proven that the nature of industrial exposure is reflected in the chemical composition of pigs\' homemade biological materials. The organs of the gastrointestinal tract actively accumulate heavy, rare-earth (Lu, Ce, La), radioactive metals (Th, U) and arsenic. The chemical affinity of a pig\'s body is domestic to human, and the analogy of the behavior of chemical elements in mammals as a whole suggests that the patterns can be attributed to humans, but this assumption requires further refinement.
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